外泌体在机体抗结核分枝杆菌感染中的作用及其应用

doi:10.11843/j.issn.0366-6964.2018.09.001

摘要/Abstract

摘要：

结核病（tuberculosis）是由结核分枝杆菌（Mycobacterium tuberculosis，Mtb）感染引起的严重危害人类健康的主要传染病之一，全球每年都会有数百万人死于结核病，但目前结核病的预防和治疗仍然未取得重大突破。外泌体（exosomes）是一种多种细胞均可分泌的囊泡结构，其内含有多种成分，它在细胞间的信息传递、机体免疫等生理过程中发挥着重要的作用。近年来的研究发现，外泌体与结核病的发生发展有密切的联系，外泌体与结核病的研究已经成为当前的研究热点之一，其在结核病的诊断和治疗中的潜在价值也越来越受到人们的关注。本文就外泌体在机体抗结核分枝杆菌感染中的作用及其应用的相关研究进展进行综述。

Abstract:

Tuberculosis (TB) is a severe pulmonary disease and a public health burden caused by the infection of Mycobacterium tuberculosis (Mtb). Every year, millions of people die of TB worldwide. Unfortunately, so far, little breakthrough progress has been made in the prevention and treatment of TB. Exosomes are small membrane vesicles that can be secreted by most cells in the body; it plays important roles in intercellular communication and other physiological processes by shuttling various molecules from donor to recipient cells. Recent studies have found that exosomes also play important roles in the host defense against Mtb infection. In this review, we summarized the role of exosomes in anti-Mtb infection and its application.

中图分类号:

徐兆坤, 李武, 王玉炯. 外泌体在机体抗结核分枝杆菌感染中的作用及其应用[J]. 畜牧兽医学报, 2018, 49(9): 1803-1809.

XU Zhao-kun, LI Wu, WANG Yu-jiong. The Roles and Applications of Exosomes in the Host Defense against Mycobacterium tuberculosis Infection[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(9): 1803-1809.

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